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Daftar Nama Pemain Arsenal Musim 2021/2022
| No. | Name | Kebangsaan | Pos |
| 1 | Bernd Leno | Jerman | GK |
| 32 | Aaron Ramsdale | Inggris | GK |
| 33 | Arthur Okonkwo | Inggris | GK |
| 3 | Kieran Tierney | Skotlandia | LB / LWB |
| 4 | Ben White | Inggris | CB |
| 6 | Gabriel | Brasil | CB |
| 16 | Rob Holding | Inggris | CB |
| 17 | Cédric Soares | Portugal | RB / RWB |
| 18 | Takehiro Tomiyasu | Jepang | RB / CB |
| 20 | Nuno Tavares | Portugal | LB / RB |
| 21 | Calum Chambers | Inggris | CB / DM / RB |
| 22 | Pablo Marí | Spanyol | CB |
| 31 | Sead Kolašinac | Bosnia | LB / LWB |
| 5 | Thomas Partey | Ghana | CM / DM |
| 8 | Martin Ødegaard | Norwegia | AM / CM |
| 10 | Emile Smith Rowe | Inggris | AM / LM |
| 15 | Ainsley Maitland-Niles | Inggris | CM / RB / LWB / RWB |
| 23 | Albert Sambi Lokonga | Belgia | CM |
| 25 | Mohamed Elneny | Mesir | DM |
| 34 | Granit Xhaka | Swiss | CM / DM |
| 7 | Bukayo Saka | Inggris | RW / LW |
| 9 | Alexandre Lacazette | Prancis | ST |
| 14 | Pierre-Emerick Aubameyang © | Gabon | ST / LW |
| 19 | Nicolas Pépé | Pantai Gading | RW |
| 26 | Folarin Balogun | Inggris | ST |
| 30 | Eddie Nketiah | Inggris | ST |
| 35 | Gabriel Martinelli | Brasil | LW / ST |
Daftar Nama Pemain Baru Arsenal Musim 2021/2022
| Pos | Nama | Dari | Ket |
| DF | Nuno Tavares | Benfica | £7.2m |
| MF | Albert Sambi Lokonga | Anderlecht | £15.75m |
| FW | Mika Biereth | Fulham | Bebas Transfer |
| DF | Ben White | Brighton & Hove Albion | £50m |
| MF | Martin Ødegaard | Real Madrid | £30m |
| GK | Aaron Ramsdale | Sheffield United | £24m |
| DF | Takehiro Tomiyasu | Bologna | £16m |
Daftar Nama Pemain yang Keluar dari Arsenal Musim 2021/2022
| Pos | Nama | Ke | Ket |
| FW | Trae Coyle | Lausanne-Sport | |
| DF | Mark McGuinness | Cardiff City | |
| DF | Zech Medley | KV Oostende | |
| MF | Aaron Benn | Watford | Free transfer |
| DF | David Luiz | Flamengo | Kontrak Berakhir |
| MF | Adebayo Fapetu | Derby County | Free transfer |
| DF | Levi Laing | West Ham United | |
| DF | Joseph Olowu | Doncaster Rovers | |
| DF | Daniel Oyegoke | Brentford | |
| FW | Luke Plange | Derby County | Free transfer |
| MF | Ben Sheaf | Coventry City | |
| DF | Jason Sraha | Barnsley | Free transfer |
| FW | Kieran Petrie | Swansea City | |
| DF | Tolaji Bola | Rotherham United | |
| MF | Joe Willock | Newcastle United | £25m |
| FW | Willian | Corinthians | Free transfer |